Cyclobutanecarboxylic acid → HCID 22611340, compound

HRID 843831Notes

Reaction equation

HRID 843831 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH:11]1[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]1.[CH:18]1([C:22](O)=[O:23])[CH2:21][CH2:20][CH2:19]1>>[CH:18]1([C:22]([NH:1][C:2]2[CH:3]=[C:4]3[C:8](=[CH:9][CH:10]=2)[NH:7][CH:6]=[C:5]3[CH:11]2[CH2:16][CH2:15][N:14]([CH3:17])[CH2:13][CH2:12]2)=[O:23])[CH2:21][CH2:20][CH2:19]1

Participants

3

Reactant 2

HCID 19494Cyclobutanecarboxylic acidHCID 118312203-(1-Methylpiperidin-4-yl)-1h-indol-5-amine

Product 1

HCID 22611340HCID 22611340, compoundYield 96.3%

Procedure

Beginning with 12.0 mg (0.05 mMol) 5-amino-3-(1-methylpiperidin-4-yl)-1H-indole and 15.0 mg (0.10 mMol) cyclobutanecarboxylic acid, 15.0 mg (96%) of the title compound were recovered.

Sources & evidence

ORD record
ord-842f03ee25884d8580dbd57021268c69
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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