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Compound 140 (0.22 g, 0.37 mmol) was dissolved in acetone (50 mL) to give a colorless solution. The reaction mixture was diluted with water (20 mL) and TFA (2 mL), and heated to reflux for 2 h. It was then cooled and concentrated. The precipitated product was isolated by suction filtration. A small amount of toluene (5 mL) was added to the wet solid, and the mixture was concentrated to remove water azeotropically. The residue was dried in vacuum to provide aldehyde 141 (0.21 g, 103% yield). MS (m/z): 553.2 (M+H).

1. customto give a colorless solution
2. temperatureheated
3. temperatureto reflux for 2 h
4. temperatureIt was then cooled
5. concentrationconcentrated
6. customThe precipitated product was isolated by suction filtration
7. concentrationthe mixture was concentrated
8. customto remove water azeotropically
9. customThe residue was dried in vacuum