Methyl isothiocyanate → HCID 54517905, compound

HRID 843896Notes

Reaction equation

HRID 843896 reaction equation
[NH2:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][CH:7]([N:15]([CH3:17])[CH3:16])[CH2:6][C:5]2=1.[CH3:18][N:19]=[C:20]=[S:21]>ClCCl>[CH3:18][NH:19][C:20]([NH:1][C:2]1[CH:3]=[C:4]2[C:12](=[CH:13][CH:14]=1)[NH:11][C:10]1[CH2:9][CH2:8][CH:7]([N:15]([CH3:17])[CH3:16])[CH2:6][C:5]2=1)=[S:21]

Participants

4

Reactant 2

HCID 11167Methyl isothiocyanateHCID 226115606-amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole

Product 1

HCID 54517905HCID 54517905, compoundYield 48%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To a solution of 10.0 mg (0.0437 mMol) 6-amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole in 3.0 mL dichloromethane were added 6.2 mg (0.0874 mMol) methyl isothiocyanate. The reaction was mixed for 48 hours and to it were then added 0.15 gm (0.0874 mMol) aminomethylated polystyrene and the reaction mixed for an additional 18 hours. The reaction mixture was then filtered and the volatiles evaporated to give 6.3 mg (48%) of the title compound.

Workup

  1. additionThe reaction was mixed for 48 hours and to it
  2. additionwere then added 0.15 gm (0.0874 mMol)
  3. additionthe reaction mixed for an additional 18 hours
  4. filtrationThe reaction mixture was then filtered
  5. customthe volatiles evaporated

Sources & evidence

ORD record
ord-26d1f679c886472b935029df225cddc4
Source dataset
uspto-grants-2002_04
Patent number
US06380201B1

Reaction notes

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