Oxalic Acid → HCID 131720393, compound

HRID 843932Notes

Reaction equation

[F:1][C:2]1[CH:26]=[CH:25][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]2[CH2:16][CH2:15][CH:14]([N:22]([CH3:24])[CH3:23])[CH2:13][C:12]3=2)=[O:7])=[CH:4][CH:3]=1.[C:27]([OH:32])(=[O:31])[C:28]([OH:30])=[O:29].C(OCC)(=O)C>>[OH2:7].[C:27]([OH:32])(=[O:31])[C:28]([OH:30])=[O:29].[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]2[CH2:16][CH2:15][CH:14]([N:22]([CH3:24])[CH3:23])[CH2:13][C:12]3=2)=[O:7])=[CH:25][CH:26]=1.[F:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][C:9]2[CH:10]=[C:11]3[C:19](=[CH:20][CH:21]=2)[NH:18][C:17]2[CH2:16][CH2:15][CH:14]([N:22]([CH3:24])[CH3:23])[CH2:13][C:12]3=2)=[O:7])=[CH:25][CH:26]=1.[C:27]([OH:32])(=[O:31])[C:28]([OH:30])=[O:29]

Participants

Reactant 3

HCID 971Oxalic Acid

HCID 8857Ethyl Acetate2×

HCID 18971832HCID 18971832, compound

Product 1

HCID 131720393HCID 131720393, compoundYield 75%

Procedure

A solution of 0.82 mg (0.23 mMol) 6-(4-fluorobenzoyl)amino-3-(dimethyl)amino-1,2,3,4-tetrahydro-9H-carbazole in 1 mL ethyl acetate were added to a solution of 0.21 mg (0.23 mMol) oxalic acid in 1 mL ethyl acetate. The solid which formed was filtered, washed with ethyl acetate and dried to give 0.77 mg (75%) of the title compound.

Workup

customThe solid which formed
filtrationwas filtered
washwashed with ethyl acetate
customdried

Sources & evidence

ORD record: ord-32e6657c9ac94bcaa74ea089aea4a92a
Source dataset: uspto-grants-2002_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06380201B1

Reaction notes

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