Potassium Carbonate → Methyl 2-(4-cyanophenoxy)-3-pyridinecarboxylate

HRID 843984Notes

Reaction equation

HRID 843984 reaction equation
[CH2:1]([O:3][C:4](=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][C:6]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=1)C.C(=O)([O-])[O-].[K+].[K+]>CO.O>[CH3:1][O:3][C:4](=[O:20])[C:5]1[CH:10]=[CH:9][CH:8]=[N:7][C:6]=1[O:11][C:12]1[CH:17]=[CH:16][C:15]([C:18]#[N:19])=[CH:14][CH:13]=1

Participants

5

Reactant 2

HCID 11430Potassium CarbonateHCID 54421279HCID 54421279, compound

Product 1

HCID 53920004Methyl 2-(4-cyanophenoxy)-3-pyridinecarboxylateYield 32.2%

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 962WaterSolvent

Procedure

A solution of 2-(4-Cyano-phenoxy)-nicotinic acid ethyl ester (0.90 grams, 2.44 mmole) in methanol (10 ml) and potassium carbonate (1.01 grams, 7.33 mmole) was refluxed for 20 minutes. The mixture was diluted with 100 ml water, acidified to pH 1 and filtered to give a solid (0.200 g). MW 254; MS (m/e) 254 (M+).

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-79f4ed80f2b2415bbd6c73a5fefa4f7c
Source dataset
uspto-grants-2002_04
Patent number
US06380218B1

Reaction notes

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