(R)-2-(3-Chloro-phenoxy)-N-(2-hydroxy-1-phenyl-ethyl)-nicotinamide → (R)-2-(3-Chloro-phenoxy)-3-(4-phenyl4,5-dihydro-oxazol-2-yl)-pyridine

HRID 844039Notes

Reaction equation

HRID 844039 reaction equation
OC1N=CC=CC=1C(N)=O.[Cl:11][C:12]1[CH:13]=[C:14]([CH:34]=[CH:35][CH:36]=1)[O:15][C:16]1[N:33]=[CH:32][CH:31]=[CH:30][C:17]=1[C:18]([NH:20][C@H:21]([C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1)[CH2:22][OH:23])=O>>[Cl:11][C:12]1[CH:13]=[C:14]([CH:34]=[CH:35][CH:36]=1)[O:15][C:16]1[C:17]([C:18]2[O:23][CH2:22][C@@H:21]([C:24]3[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=3)[N:20]=2)=[CH:30][CH:31]=[CH:32][N:33]=1

Participants

3

Reactant 2

HCID 53928194(R)-2-(3-Chloro-phenoxy)-N-(2-hydroxy-1-phenyl-ethyl)-nicotinamideHCID 178513660HCID 178513660, compound

Product 1

HCID 54499932(R)-2-(3-Chloro-phenoxy)-3-(4-phenyl4,5-dihydro-oxazol-2-yl)-pyridine

Procedure

The compound of Example 129 was prepared according to the procedure of Example 128 substituting the corresponding hydroxy nicotinamide for (R)-2-(3-Chloro-phenoxy)-N-(2-hydroxy-1-phenyl-ethyl)-nicotinamide. The duration of reaction was between 1 and 24 hours.

Workup

  1. customThe duration of reaction
  2. waitwas between 1 and 24 hours

Sources & evidence

ORD record
ord-675c3815f7b0471a919d5dffb85c52ab
Source dataset
uspto-grants-2002_04
Patent number
US06380218B1

Reaction notes

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