Acetic Acid → HCID 15549834, compound

HRID 844217Notes

Reaction equation

HRID 844217 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].C[C:12]1[CH:13]=[C:14]2[C:19](=[O:20])[O:18][C:16](=O)[C:15]2=[CH:21][CH:22]=1.[C:23](O)(=O)C>>[CH3:23][C:13]1[CH:12]=[CH:22][CH:21]=[C:15]2[C:14]=1[C:19](=[O:20])[N:1]([CH:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6])[C:16]2=[O:18]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 33032L-Glutamic AcidHCID 880694-Methylphthalic anhydride

Product 1

HCID 15549834HCID 15549834, compound

Procedure

A mixture of glutamic acid (10 mmol) and 4-methyphthalic anhydride below (10 mmol) in 20 mL of acetic acid is heated to reflux. The cooled reaction is then concentrated in vacuo. The residue is slurried in ethyl acetate and the resulting slurry filtered to afford the desired product. As an alternative to slurry filtering, column chromatography can be used to purify the desired product.

Workup

  1. temperatureis heated to reflux
  2. customThe cooled reaction
  3. concentrationis then concentrated in vacuo
  4. filtrationthe resulting slurry filtered

Sources & evidence

ORD record
ord-12c4555af78b4cfc9215db93f25fd17f
Source dataset
uspto-grants-2002_04
Patent number
US06380239B1

Reaction notes

Loading…