Acetic Acid → HCID 15549834, compound

Participants

Reaction Steps

A mixture of glutamic acid (10 mmol) and 4-methyphthalic anhydride below (10 mmol) in 20 mL of acetic acid is heated to reflux. The cooled reaction is then concentrated in vacuo. The residue is slurried in ethyl acetate and the resulting slurry filtered to afford the desired product. As an alternative to slurry filtering, column chromatography can be used to purify the desired product.

Provenance & Evidence