反应详情

A mixture of glutamine (10 mmol) and 3-nitrophthalic anhydride (10 mmol) in 15 ml of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue purified by chromatography to afford 2-(4-nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.

1. temperatureis heated to reflux
2. customThe cooled reaction mixture
3. concentrationis concentrated
4. customthe residue purified by chromatography