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L-Glutamine → 2-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | L-Glutamine | HCID 5961 | — |
| 反応物 | 3-Nitrophthalic anhydride | HCID 21631 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 生成物 | 2-(4-Nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid | HCID 15549838 | — |
反応手順
A mixture of glutamine (10 mmol) and 3-nitrophthalic anhydride (10 mmol) in 15 ml of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue purified by chromatography to afford 2-(4-nitro-1,3-dioxoisoindolin-2-yl)-4-carbamoylbutanoic acid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US06380239B1 |
| 出典データセット | uspto-grants-2002_04 |
| ORD ID | ord-bf66b1f98d1f4d3cb6def6eed68fed3d |
| 出典メモ | uspto-grants-2002_04 |