Sodium Carbonate → HCID 22612815, compound

HRID 844222Notes

Reaction equation

HRID 844222 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:11](=O)([O-])[O-].[Na+].[Na+].[N+:17]([C:20]1[CH:21]=[C:22]2[C:27](=[O:28])OC(=O)[C:23]2=[CH:29][CH:30]=1)([O-:19])=[O:18]>O>[N+:17]([C:20]1[CH:30]=[CH:29][CH:23]=[C:22]2[C:21]=1[CH2:11][N:1]([CH:2]([CH2:3][CH2:4][C:5]([OH:7])=[O:6])[C:8]([OH:10])=[O:9])[C:27]2=[O:28])([O-:19])=[O:18]

Participants

5

Reactant 3

HCID 10340Sodium CarbonateHCID 33032L-Glutamic AcidHCID 2309764-Nitrophthalic acid anhydride

Product 1

HCID 22612815HCID 22612815, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To a stirred solution of glutamic acid (10 mmol) and sodium carbonate (10.5 mmol) in water (50 mL) is added 4-nitrophthalic anhydride (10 mmol). The resulting mixture is stirred for 3 hours. The mixture is filtered. The filtrate is then acidified to pH 1 with 4 N hydrochloric acid to afford 2-(4-nitro-1-oxoisoindolin-2-yl)glutaric acid.

Workup

  1. filtrationThe mixture is filtered

Sources & evidence

ORD record
ord-4b788eac092f4e6e895fb8d5aa99ea0e
Source dataset
uspto-grants-2002_04
Patent number
US06380239B1

Reaction notes

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