Sodium Carbonate → HCID 22612815, compound

Participants

Reaction Steps

To a stirred solution of glutamic acid (10 mmol) and sodium carbonate (10.5 mmol) in water (50 mL) is added 4-nitrophthalic anhydride (10 mmol). The resulting mixture is stirred for 3 hours. The mixture is filtered. The filtrate is then acidified to pH 1 with 4 N hydrochloric acid to afford 2-(4-nitro-1-oxoisoindolin-2-yl)glutaric acid.

Provenance & Evidence