Acetic Acid → HCID 15549840, compound

HRID 844223Notes

Reaction equation

HRID 844223 reaction equation
[NH2:1][C@H:2]([C:8]([OH:10])=[O:9])[CH2:3][CH2:4][C:5](=[O:7])[NH2:6].[N+:11]([C:14]1[CH:15]=[C:16]2[C:21](=[O:22])OC(=O)[C:17]2=[CH:23][CH:24]=1)([O-:13])=[O:12].[C:25](O)(=O)C>>[N+:11]([C:14]1[CH:24]=[CH:23][CH:17]=[C:16]2[C:15]=1[CH2:25][N:1]([CH:2]([CH2:3][CH2:4][C:5](=[O:7])[NH2:6])[C:8]([OH:10])=[O:9])[C:21]2=[O:22])([O-:13])=[O:12]

Participants

4

Reactant 3

HCID 176Acetic AcidHCID 5961L-GlutamineHCID 2309764-Nitrophthalic acid anhydride

Product 1

HCID 15549840HCID 15549840, compound

Procedure

A mixture of glutamine (10 mmol) and 4-nitrophthalic anhydride (10 mmol) in 15 mL of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue purified by chromatography to afford 2-(4-nitro-1-oxoisoindolin-2-yl)-4-carbamoylbutanoic acid.

Workup

  1. temperatureis heated to reflux
  2. customThe cooled reaction mixture
  3. concentrationis concentrated
  4. customthe residue purified by chromatography

Sources & evidence

ORD record
ord-15ba21be2d744e5abc16dcf157368b03
Source dataset
uspto-grants-2002_04
Patent number
US06380239B1

Reaction notes

Loading…