HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → Lenalidomide impurity 13
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | L-Glutamine | HCID 5961 | — |
| Reactant | 4-Nitrophthalic acid anhydride | HCID 230976 | — |
| Product | Lenalidomide impurity 13 | HCID 15549840 | — |
Reaction Steps
A mixture of glutamine (10 mmol) and 4-nitrophthalic anhydride (10 mmol) in 15 mL of acetic acid is heated to reflux. The cooled reaction mixture is concentrated and the residue purified by chromatography to afford 2-(4-nitro-1-oxoisoindolin-2-yl)-4-carbamoylbutanoic acid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380239B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-15ba21be2d744e5abc16dcf157368b03 |
| Source note | uspto-grants-2002_04 |