Sodium Hydroxide → HCID 22613081, compound

HRID 844360Notes

Reaction equation

HRID 844360 reaction equation
C([O:3][C:4](=[O:23])[C:5](=[O:22])[CH2:6][C:7](=[O:21])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)[CH:9]=1)C.[OH-].[Na+]>CO.CC(O)=O.C(Cl)Cl>[O:22]=[C:5]([CH2:6][C:7](=[O:21])[C:8]1[CH:13]=[CH:12][CH:11]=[C:10]([S:14][C:15]2[CH:16]=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH:9]=1)[C:4]([OH:23])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86758010HCID 86758010, compound

Product 1

HCID 22613081HCID 22613081, compound

Reagents, catalysts & solvents 1

HCID 21877243DCM MeOH AcOHSolvent

Procedure

In a manner similar to example AIV-2-1, 2,4-dioxo-4-(3-phenylsulfanyl-phenyl)-butyric acid ethyl ester was formed and the crude material was hydrolyzed in a manner similar to example AIV-3-1 using 1N NaOH to afford L-1 as a yellow solid. Rf=0.32 (6:6:94 MeOH/AcOH/CH2Cl2).

Workup

  1. customto afford L-1 as a yellow solid

Sources & evidence

ORD record
ord-666ee53fd5c845fd8ecab7befba5d744
Source dataset
uspto-grants-2002_04
Patent number
US06380249B1

Reaction notes

Loading…