Acetone → Benzoic acid, isopropylidenehydrazide

HRID 844390Notes

Reaction equation

HRID 844390 reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:11][C:12]([CH3:14])=O>>[CH3:11][C:12](=[N:10][NH:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH3:14]

Participants

3

Reactant 2

HCID 180AcetoneHCID 11955Benzoylhydrazine

Product 1

HCID 18868Benzoic acid, isopropylidenehydrazide

Conditions

Temperature
5 °C

Procedure

A four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer was charged with 136 g (1.0 mol) of benzohydrazide and 600 ml of acetone and then heated under reflux for 12 hours. The reaction liquid was cooled down to 5° C. or lower, and then crystal was filtered off and dried under reduced pressure, whereby white crystal was obtained.

Workup

  1. customA four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer
  2. temperatureheated
  3. temperatureunder reflux for 12 hours
  4. customThe reaction liquid
  5. filtrationlower, and then crystal was filtered off
  6. customdried under reduced pressure, whereby white crystal
  7. customwas obtained

Sources & evidence

ORD record
ord-e8b7f8ad3dd4478a8d5ef3d40e99e176
Source dataset
uspto-grants-2002_04
Patent number
US06380288B1

Reaction notes

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