Benzoylhydrazine → HCID 4184920, compound

HRID 844392Notes

Reaction equation

HRID 844392 reaction equation
[C:1]([NH:9][NH2:10])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(C(C)=O)C(C)C>[CH3:5][C:4](=[N:10][NH:9][C:1](=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1)[CH2:3][CH:2]([CH3:7])[CH3:1]

Participants

3

Reactant 1

HCID 11955Benzoylhydrazine

Product 1

HCID 4184920HCID 4184920, compound

Reagents, catalysts & solvents 1

HCID 7909Methyl Isobutyl KetoneSolvent

Conditions

Temperature
5 °C

Procedure

A four neck flask (2 liters) equipped with a thermometer, a Dean-Stark type reflux condenser and a stirrer was charged with 68.0 g (0.5 mol) of benzohydrazide and 600 ml of methyl isobutyl ketone and then heated under reflux for 5 hours. The reaction liquid was cooled down to 5° C. or lower, and then crystal was filtered off and dried under reduced pressure, whereby white crystal was obtained.

Workup

  1. customA four neck flask (2 liters) equipped with a thermometer
  2. temperaturea Dean-Stark type reflux condenser and a stirrer
  3. temperatureheated
  4. temperatureunder reflux for 5 hours
  5. customThe reaction liquid
  6. filtrationlower, and then crystal was filtered off
  7. customdried under reduced pressure, whereby white crystal
  8. customwas obtained

Sources & evidence

ORD record
ord-f295fddda70a46598304e74e50797222
Source dataset
uspto-grants-2002_04
Patent number
US06380288B1

Reaction notes

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