反应详情

A four neck flask (2 liters) equipped with a thermometer, a reflux condenser and a stirrer was charged with 76.1 g (0.5 mol) of salicylohydrazide and 1 liter of methanol, and 57.6 g (0.6 mol) of furfural was dropwise added thereto in 30 minutes while stirring at room temperature. After heating under reflux for 2 hours, the reaction liquid was cooled down to 20° C. or lower, and crystal was filtered off. The crystal was washed with a small amount of methanol and then dried under reduced pressure, whereby the intended compound (slightly yellow crystal) was obtained. The amount yielded in this reaction was 108.1 g (0.47 mol), and the yield was 93%.

1. customA four neck flask (2 liters) equipped with a thermometer, a reflux condenser and a stirrer
2. additionwas dropwise added
3. temperatureAfter heating
4. temperatureunder reflux for 2 hours
5. customthe reaction liquid
6. temperaturewas cooled down to 20° C.
7. filtrationlower, and crystal was filtered off
8. washThe crystal was washed with a small amount of methanol
9. customdried under reduced pressure, whereby the intended compound (slightly yellow crystal)
10. customwas obtained
11. customThe amount yielded in this reaction