Benzaldehyde → HCID 54199952, compound

HRID 844409Notes

Reaction equation

HRID 844409 reaction equation
[C:1]1([S:11]([NH:14][NH2:15])(=[O:13])=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[CH:16](=O)[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>CO>[CH:16](=[N:15][NH:14][S:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)(=[O:12])=[O:13])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

Participants

4

Reactant 2

HCID 240BenzaldehydeHCID 12424878HCID 12424878, compound

Product 1

HCID 54199952HCID 54199952, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer was charged with 111 g (0.5 mol) of 1-naphthalenesulfonohydrazide and 700 ml of methanol, and 63.6 g (0.6 mol) of benzaldehyde was dropwise added thereto in one hour while stirring at room temperature and heated under reflux for about 5 hours. The reaction liquid was cooled down to 20° C. or lower, and then crystal was filtered off and dried under reduced pressure, whereby white crystal was obtained.

Workup

  1. customA four neck flask (1 liter) equipped with a thermometer, a reflux condenser and a stirrer
  2. additionwas dropwise added
  3. temperatureheated
  4. temperatureunder reflux for about 5 hours
  5. customThe reaction liquid
  6. temperaturewas cooled down to 20° C.
  7. filtrationlower, and then crystal was filtered off
  8. customdried under reduced pressure, whereby white crystal
  9. customwas obtained

Sources & evidence

ORD record
ord-c49e74b0801c4f7881cbacf775bdcba5
Source dataset
uspto-grants-2002_04
Patent number
US06380288B1

Reaction notes

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