反应详情

温度

0 °C

10 g of 2,4-dimethoxychlorobenzene and 10.93 g of 4-cyclohexanebutyryl chloride obtained in step 1 of Preparation 1.1 in 100 ml of CCl4 are mixed together at 0° C. and 6.35 ml of TiCl4 are added. After stirring for 2 hours at 0° C., the mixture is poured onto ice-cold 1N HCl solution and the organic phase is then separated out by settling and washed with 0.5N NaOH. After drying over MgSO4 and evaporation of the solvent, 20 g of the expected product are obtained.

1. additionare mixed together at 0° C.
2. additionthe mixture is poured onto ice-cold 1N HCl solution
3. customthe organic phase is then separated out
4. washwashed with 0.5N NaOH
5. dry with materialAfter drying over MgSO4 and evaporation of the solvent, 20 g of the expected product
6. customare obtained