HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Chloro-2,4-dimethoxybenzene → 4-Cyclohexyl-1-(5-chloro-2,4-dimethoxyphenyl)butan-1-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Chloro-2,4-dimethoxybenzene | HCID 138905 | — |
| Reactant | 4-Cyclohexylbutanoyl chloride | HCID 13315625 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Carbon Tetrachloride | HCID 5943 | — |
| Product | 4-Cyclohexyl-1-(5-chloro-2,4-dimethoxyphenyl)butan-1-one | HCID 22612576 | — |
Reaction Conditions
| Temperature | 0 °C |
|---|
Reaction Steps
10 g of 2,4-dimethoxychlorobenzene and 10.93 g of 4-cyclohexanebutyryl chloride obtained in step 1 of Preparation 1.1 in 100 ml of CCl4 are mixed together at 0° C. and 6.35 ml of TiCl4 are added. After stirring for 2 hours at 0° C., the mixture is poured onto ice-cold 1N HCl solution and the organic phase is then separated out by settling and washed with 0.5N NaOH. After drying over MgSO4 and evaporation of the solvent, 20 g of the expected product are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06380230B1 |
| Source dataset | uspto-grants-2002_04 |
| ORD ID | ord-853b0adaf15c4e308cf98017c60409f8 |
| Source note | uspto-grants-2002_04 |