Hydrochloric Acid → 1-Benzyl-1,2-dihydro-2-oxoquinoxaline-3-carboxylic acid

HRID 844519Notes

Reaction equation

HRID 844519 reaction equation
[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([C:18]([O:20]CC)=[O:19])[C:9]1=[O:23])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+].Cl>C(O)C>[CH2:1]([N:8]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[N:11]=[C:10]([C:18]([OH:20])=[O:19])[C:9]1=[O:23])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 15461773HCID 15461773, compound

Product 1

HCID 154617741-Benzyl-1,2-dihydro-2-oxoquinoxaline-3-carboxylic acidYield 95.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To 2.00 g of ethyl 1-benzyl-1,2-dihydro-2-oxoquinoxaline-3-carboxylate were added 10 ml of ethanol and 20 ml of 10% aqueous sodium hydroxide solution, followed by stirring at room temperature for an hour. To the reaction solution was added dropwise 3 N hydrochloric acid to make acidic (pH=3.0), and the precipitated crystals were collected by filtration and washed with water and diethyl ether to give 1.73 g of 1-benzyl-1,2-dihydro-2-oxoquinoxaline-3-carboxylic acid.

Workup

  1. filtrationthe precipitated crystals were collected by filtration
  2. washwashed with water and diethyl ether

Sources & evidence

ORD record
ord-1559956b60a440b9af7166edc4b3cf99
Source dataset
uspto-grants-2002_04
Patent number
US06380384B1

Reaction notes

Loading…