HRID844589

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID784

Hydrogen peroxide

H2O2

HCID24823

Ozone

结构：C=C[C@](C)(O)CC[C@@H]1[C@@]2(C)CCCC(C)(C)[C@@H]2CC[C@@]1(C)O

HCID163263

Sclareol

C20H36O2

PRODUCTS

生成物

结构：CC1=CC[C@@H]2[C@@]3(C)CCCC(C)(C)[C@@H]3CC[C@@]2(C)O1

HCID7057250

(+)-Sclareol oxide

C18H30O

PROCEDURE

实验过程

Sclareol is oxidised with ozone, followed by treatment with alkaline hydrogen peroxide to give sclareol oxide. The sclareol oxide is then oxidised with an organic hydroperoxide, preferably tert-butyl hydroperoxide, to give 12-acetyl-norlabdane oxide. The 12-acetyl-norlabdane oxide is converted to 12-acetoxy-norlabdane oxide by oxidation with an organic peracid, preferably peracetic acid. The 12-acetoxy-norlabdane oxide is then reduced to norlabdane oxide with sodium borohydride in the presence of a transition metal salt. The reaction scheme of EP 0882191A may be represented as follows: