Cesium carbonate → HCID 15427532, compound

HRID 844611Notes

Reaction equation

HRID 844611 reaction equation
O[C:2]1[CH:3]=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].[C:10](=[O:13])([O-])[O-].[Cs+].[Cs+]>C(#N)C>[C:5]([C:4]1[CH:7]=[C:8]([CH:9]=[CH:2][CH:3]=1)[O:13][CH2:10][C:2]1[CH:9]=[C:8]([C:2]2[CH:9]=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[CH:3]=2)[CH:7]=[CH:4][CH:3]=1)#[N:6]

Participants

4

Reactant 2

HCID 10796Cesium carbonateHCID 133943-Cyanophenol

Product 1

HCID 15427532HCID 15427532, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 500 mg of “B” and 238 mg of 3-hydroxybenzonitrile in 10 ml of acetonitrile is treated with 652 mg of caesium carbonate and stirred at room temperature for 40 hours. After customary working up, the residue is chromatographed on a reversed-phase column using acetonitrile/water 65:35. 3′-(3-Cyanophenoxymethyl)biphenyl-3-carbonitrile (“C”), FAB 311, is obtained as a colourless solid.

Workup

  1. customthe residue is chromatographed on a reversed-phase column

Sources & evidence

ORD record
ord-d2e4f655395a4ca894835c59968c2c57
Source dataset
uspto-grants-2002_04
Patent number
US06380430B1

Reaction notes

Loading…