Methyl 3-bromobenzoate → HCID 1392448, compound

HRID 844613Notes

Reaction equation

HRID 844613 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:9]=[CH:10][CH:11]=1)[C:5]([O:7][CH3:8])=[O:6].[C:12]1([CH3:21])[CH:17]=[CH:16][CH:15]=[C:14](B(O)O)[CH:13]=1>>[CH3:21][C:12]1[CH:13]=[C:14]([C:2]2[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=2)[CH:15]=[CH:16][CH:17]=1

Participants

3

Reactant 2

HCID 12070Methyl 3-bromobenzoateHCID 27339503-Tolylboronic acid

Product 1

HCID 1392448HCID 1392448, compound

Procedure

Analogously to Example 1, by reaction of methyl 3-bromobenzoate with 3-tolylboronic acid, methyl 3′-methylbiphenyl-3-carboxylate is obtained. By bromination with NBS and reaction with methyl 3-hydroxybenzoate, methyl 3′-(3-methoxycarbonylphenoxymethyl)biphenyl-3-carboxylate is obtained therefrom. By reaction with guanidine hydrochloride in methanolic sodium methoxide solution, N-[3′-(3-guanidinocarbonylphenoxymethyl)biphenyl-3-carbonyl]-guanidine

Sources & evidence

ORD record
ord-37a2aa289ae840449011f69113abfb88
Source dataset
uspto-grants-2002_04
Patent number
US06380430B1

Reaction notes

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