Potassium Carbonate → HCID 22568804, compound

HRID 844785Notes

Reaction equation

HRID 844785 reaction equation
[CH3:1][C:2]1[CH:13]=[C:12]([C:14]#[C:15][Si](C)(C)C)[CH:11]=[CH:10][C:3]=1[CH2:4][N:5]1[CH:9]=[CH:8][N:7]=[CH:6]1.C(=O)([O-])[O-].[K+].[K+]>CO>[C:14]([C:12]1[CH:11]=[CH:10][C:3]([CH2:4][N:5]2[CH:9]=[CH:8][N:7]=[CH:6]2)=[C:2]([CH3:1])[CH:13]=1)#[CH:15]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 225689641-(2-Methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole2×

Product 1

HCID 22568804HCID 22568804, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; 1-(2-methyl-4-trimethylsilanylethynyl-benzyl)-1H-imidazole (Intermediate 140, 140.0 mg, 0.53 mmols) in methanol (5 mL) was treated with potassium carbonate (100.0 mg, 0.72 mmol) and stirred overnight at ambient temperature. The crude alkyne (105 mg, 100%) was use d directly in the next reaction.

Workup

  1. customd directly in the next reaction

Sources & evidence

ORD record
ord-61e6f48dd34747b683045f26123de819
Source dataset
uspto-grants-2002_04
Patent number
US06380256B1

Reaction notes

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