Potassium Carbonate → HCID 18710218, compound

HRID 844814Notes

Reaction equation

HRID 844814 reaction equation
[CH:1]([C:4]1[CH:5]=[C:6]([C:16]#[C:17][Si](C)(C)C)[CH:7]=[CH:8][C:9]=1[CH2:10][O:11][C:12]1([CH3:15])[CH2:14][CH2:13]1)([CH3:3])[CH3:2].C(=O)([O-])[O-].[K+].[K+]>CO>[C:16]([C:6]1[CH:7]=[CH:8][C:9]([CH2:10][O:11][C:12]2([CH3:15])[CH2:13][CH2:14]2)=[C:4]([CH:1]([CH3:3])[CH3:2])[CH:5]=1)#[CH:17]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 69548710[3-Isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane2×

Product 1

HCID 18710218HCID 18710218, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Using General Procedure E; [3-isopropyl-4-(1-methyl-cyclopropoxymethyl)-phenylethynyl]-trimethylsilane (Intermediate 165, 110.0 mg, 0.37 mmol) in methanol (6 mL) was treated with potassium carbonate (80.0 mg, 0.58 mmol) and stirred overnight at ambient temperature. The crude alkyne (84 mg, 100%) was used directly in the next reaction.

Sources & evidence

ORD record
ord-824b3859839548dbae8a2fec166063ae
Source dataset
uspto-grants-2002_04
Patent number
US06380256B1

Reaction notes

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