Dichloroacetyl chloride → HCID 20133046, compound

Participants

Reaction Steps

By procedures described in Example 1 (Method A), β-methyl-phenethylamine and propionyl chloride were converted to 1-ethyl-4-methyl-1,2,3,4-tetrahydroisoquinoline. A reaction vessel was charged with 8 g of this isoquinoline compound, 10 ml 10% sodium hydroxide and 50 ml methylene chloride. With this mixture stirred, 1.1 equivalents dichloroacetyl chloride was added dropwise to the mixture. The mixture was stirred for 2 minutes, then water was added. The organic extract was dried with magnesium sulfate and stripped solvent. The residue was recrystallized from cyclohexane to provide 4 g of a white solid product having the elemental analysis reported in Table I.

Provenance & Evidence