Tris(hydroxymethyl)aminomethane → HCID 131715622, compound

Participants

Reaction Steps

12.1 Grams (0.1 mol) of tris(hydroxymethyl)methylamine (from Aldrich Chemical Co.) is dissolved in 125 ml of water. To this solution is slowly added about 0.12 mole (a 20% excess) of epichlorhydrin (Aldrich Chemical). After stirring for one hour at ambient temperature, the solution is extracted twice using 50 ml of methylene chloride to remove the unreacted epichlorhydrin. The aqueous phase containing the reactive Cl-compound is used immediately.

Provenance & Evidence