Tris(hydroxymethyl)aminomethane → HCID 131715622, compound

HRID 845002Notes

Reaction equation

HRID 845002 reaction equation
[OH:1][CH2:2][C:3]([CH2:7][OH:8])([CH2:5][OH:6])[NH2:4].[CH2:9]([CH:11]1[O:13][CH2:12]1)[Cl:10]>O>[Cl:10][CH2:9][CH:11]([CH2:12][NH:4][C:3]([CH2:7][OH:8])([CH2:5][OH:6])[CH2:2][OH:1])[OH:13]

Participants

4

Reactant 2

HCID 6503Tris(hydroxymethyl)aminomethaneHCID 7835Epichlorohydrin

Product 1

HCID 131715622HCID 131715622, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

12.1 Grams (0.1 mol) of tris(hydroxymethyl)methylamine (from Aldrich Chemical Co.) is dissolved in 125 ml of water. To this solution is slowly added about 0.12 mole (a 20% excess) of epichlorhydrin (Aldrich Chemical). After stirring for one hour at ambient temperature, the solution is extracted twice using 50 ml of methylene chloride to remove the unreacted epichlorhydrin. The aqueous phase containing the reactive Cl-compound is used immediately.

Workup

  1. extractionthe solution is extracted twice
  2. customto remove the unreacted epichlorhydrin
  3. additionThe aqueous phase containing the reactive Cl-compound

Sources & evidence

ORD record
ord-1b55ac5b88ef48a1909a926f40a534d1
Source dataset
uspto-grants-1988_07
Patent number
US04755298

Reaction notes

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