Ethanol → 2-(4-methoxyphenyl)pyrazine

HRID 845017Notes

Reaction equation

HRID 845017 reaction equation
[CH2:1]([NH2:4])[CH2:2][NH2:3].O.C[C:7]1[CH:12]=[CH:11][C:10]([C:13]([CH:15]=O)=O)=[CH:9][CH:8]=1.[OH-].[K+].[CH2:19]([OH:21])C>>[CH3:19][O:21][C:7]1[CH:8]=[CH:9][C:10]([C:13]2[CH:15]=[N:4][CH:1]=[CH:2][N:3]=2)=[CH:11][CH:12]=1

Participants

5

Reactant 4

HCID 702EthanolHCID 3301EthylenediamineHCID 14797Potassium HydroxideHCID 21298530HCID 21298530, compound

Product 1

HCID 112754552-(4-methoxyphenyl)pyrazineYield 37%

Procedure

The procedure of Example 1 was repeated, using 10.68 g (0.178 mol) of ethylenediamine, 27.0 g (0.148 mol) of 4-methylphenylglyoxal monohydrate, 200 ml of ethanol and 9.01 g of potassium hydroxide. 10.1 g of the titled compound was produced (yield: 37%).

Sources & evidence

ORD record
ord-cccb62186aa54415b54b0bcd76789633
Source dataset
uspto-grants-1988_07
Patent number
US04755514

Reaction notes

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