HCID 14154537, compound → HCID 14154538, compound

HRID 845039Notes

Reaction equation

HRID 845039 reaction equation
[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([C:15]3[O:16][CH:17]=[CH:18][CH:19]=3)=[N:9][C:8]=2[N:7]([CH2:20][CH2:21][CH3:22])[C:5]1=[O:6])[CH2:2][CH3:3]>CO.[Ni]>[CH2:1]([N:4]1[C:13](=[O:14])[C:12]2[NH:11][C:10]([CH:15]3[CH2:19][CH2:18][CH2:17][O:16]3)=[N:9][C:8]=2[N:7]([CH2:20][CH2:21][CH3:22])[C:5]1=[O:6])[CH2:2][CH3:3]

Participants

4

Reactant 1

HCID 14154537HCID 14154537, compound

Product 1

HCID 14154538HCID 14154538, compoundYield 95.9%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 887MethanolSolvent

Procedure

0.35 g 1,3-Dipropyl-8-(2-furanyl)xanthine is dissolved in 50 ml methanol, to which is added 0.5 g Raney nickel and the mixture reduced under a hydrogen atmosphere of 200 psi at 100° C. The mixture is then filtered, the filtrate concentrated to yield 0.34 g of the 1,3-dipropyl-8-(2-tetrahydrofuranyl)xanthine as a white solid, mp 155°-8° C.

Workup

  1. customreduced under a hydrogen atmosphere of 200 psi at 100° C
  2. filtrationThe mixture is then filtered
  3. concentrationthe filtrate concentrated

Sources & evidence

ORD record
ord-8d9c39d7deac43f68cf754ec221b64b4
Source dataset
uspto-grants-1988_07
Patent number
US04755517

Reaction notes

Loading…