Methanol → HCID 13676515, compound

HRID 845056Notes

Reaction equation

HRID 845056 reaction equation
[I-].[C:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[CH:11]([N+](C)(C)C)[CH2:10][CH2:9]2)(=[O:4])[CH3:3].[C-:21]#[N:22].[K+].[CH3:24]O>O>[C:2]([NH:5][C:6]1[CH:7]=[C:8]2[C:13](=[CH:14][CH:15]=1)[C:12](=[O:16])[CH:11]([CH2:24][C:21]#[N:22])[CH2:10][CH2:9]2)(=[O:4])[CH3:3]

Participants

5

Reactant 3

HCID 887MethanolHCID 9032Potassium CyanideHCID 86742260HCID 86742260, compound

Product 1

HCID 13676515HCID 13676515, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Procedure

6-Acetamido-1-oxo-1,2,3,4-tetrahydro-2-naphthyl trimethylammonium iodide (4.25 g) in methanol (30 ml )/water (40 ml ) was added to a stirred solution of potassium cyanide (1.62 g) in water (40 ml ). After 3 hours the precipitate which had formed was collected and dried to give 6-acetamido-2-cyanomethyl-1-tetralone (1.7 g; m.p. 189°-90°) ν(Nujol mull) 3350-3100, 2220, 1670, 1590cm-1 ; m+ 242.

Workup

  1. customAfter 3 hours the precipitate which had formed
  2. customwas collected
  3. customdried

Sources & evidence

ORD record
ord-287c9fbcbb554f7d96dfefa92ab55629
Source dataset
uspto-grants-1988_07
Patent number
US04755511

Reaction notes

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