Methylamine → 3-chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)-N-methylbenzamide

HRID 84510Notes

Reaction equation

HRID 84510 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][N:13]=[C:12]1[C:16]1[S:29][C:19]2[C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[O:22][CH2:23][CH2:24][C:18]=2[CH:17]=1)[C:5]([OH:7])=O.[CH3:30][NH2:31]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]1[CH:15]=[N:14][N:13]=[C:12]1[C:16]1[S:29][C:19]2[C:20]3[CH:28]=[CH:27][CH:26]=[CH:25][C:21]=3[O:22][CH2:23][CH2:24][C:18]=2[CH:17]=1)[C:5]([NH:31][CH3:30])=[O:7]

Participants

3

Reactant 2

HCID 6329MethylamineHCID 579003043-Chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)benzoic acid

Product 1

HCID 579003293-chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)-N-methylbenzamide

Procedure

3-Chloro-4-(3-(4,5-dihydrobenzo[b]thieno[2,3-d]oxepin-2-yl)-4H-1,2,4-triazol-4-yl)benzoic acid and methylamine were reacted by a procedure similar to that to prepare 137 in Example 47 to give 209. MS: (ESI+) 437.1

Workup

  1. customthat to prepare 137 in Example 47

Sources & evidence

ORD record
ord-1a7365daf2e7490eb5feacb1350dd2f5
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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