1,3-Dibromopropane → HCID 15611178, compound

HRID 845121Notes

Reaction equation

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][C:7]#[N:8].Br[CH2:10][CH2:11][CH2:12]Br>>[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1([CH2:7][NH2:8])[CH2:12][CH2:11][CH2:10]1

Participants

Reactant 2

HCID 80011,3-Dibromopropane

HCID 728802-Thienylacetonitrile

Product 1

HCID 15611178HCID 15611178, compoundYield 55%

Procedure

(1-Thien-2-ylcyclobutyl)methylamine is prepared from thien-2-ylacetonitrile (3.70 g, 30 mmol), 1,3-dibromopropane (9.09 g, 45 mmol), as described in Example 1 in 55% yield.

Sources & evidence

ORD record: ord-50fcae34c29446fb8e6e18cbb3415d3b
Source dataset: uspto-grants-1988_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04755594

Reaction notes

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