Chlorotrifluoroethylene → HCID 14665049, compound

HRID 845173Notes

Reaction equation

HRID 845173 reaction equation
[Cl:1][C:2]([F:6])=[C:3]([F:5])[F:4].[Cl:7][C:8]1[CH:9]=[C:10]([OH:15])[CH:11]=[N:12][C:13]=1[Cl:14].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[Cl:1][CH:2]([F:6])[C:3]([F:5])([F:4])[O:15][C:10]1[CH:11]=[N:12][C:13]([Cl:14])=[C:8]([Cl:7])[CH:9]=1

Participants

5

Reactant 3

HCID 6594ChlorotrifluoroethyleneHCID 11430Potassium CarbonateHCID 143916722,3-Dichloro-5-hydroxypyridine

Product 1

HCID 14665049HCID 14665049, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Chlorotrifluoroethylene was passed into a mixture of 16.4 g (0.1 mol) of 5,6-dichloro-3-pyridinol I/29 and 20 g (0.145 mol) of anhydrous potassium carbonate in 100 ml of absolute acetonitrile at 35° C. until starting material was no longer present. The solid was filtered off under suction, the solvent was removed by distillation, and the residue was taken up in ether and washed until neutral. After drying over MgSO4 and removal of the ether by distillation, the residue was distilled in a high vacuum.

Workup

  1. filtrationThe solid was filtered off under suction
  2. customthe solvent was removed by distillation
  3. washwashed until neutral
  4. dry with materialAfter drying over MgSO4 and removal of the ether by distillation
  5. distillationthe residue was distilled in a high vacuum

Sources & evidence

ORD record
ord-de3c0c64ad10459ca0a8c6f10c052300
Source dataset
uspto-grants-1988_07
Patent number
US04756739

Reaction notes

Loading…