Hydrogen Peroxide → 5,6-Dichloro-3-pyridinol-1-oxide

HRID 845181Notes

Reaction equation

HRID 845181 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[N:6][C:7]=1[Cl:8].[OH:10]O>C(O)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]([OH:9])[CH:5]=[N+:6]([O-:10])[C:7]=1[Cl:8]

Participants

4

Reactant 2

HCID 784Hydrogen PeroxideHCID 143916722,3-Dichloro-5-hydroxypyridine

Product 1

HCID 147400525,6-Dichloro-3-pyridinol-1-oxide

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

3.28 g (20 mmol) of 5,6-dichloro-3-pyridinol in 15 ml of glacial acetic acid were N-oxidized at 100° C. using 2.14 g (21 mmol) of 35% hydrogen peroxide. When the reaction was complete, the mixture was neutralized, extracted with ethyl acetate and washed until neutral, and the solvent was removed by evaporation.

Workup

  1. customwere N-oxidized at 100° C.
  2. extractionextracted with ethyl acetate
  3. washwashed until neutral, and the solvent
  4. customwas removed by evaporation

Sources & evidence

ORD record
ord-db609d68e9654624a985a30d41261a44
Source dataset
uspto-grants-1988_07
Patent number
US04756739

Reaction notes

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