Potassium Carbonate → HCID 20028636, compound

HRID 845183Notes

Reaction equation

HRID 845183 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[C:7]([Cl:10])[C:8]=1[OH:9])[NH2:5].Cl[C:12]1[C:17]([Cl:18])=[CH:16][C:15]([O:19][CH:20]([F:22])[F:21])=[CH:14][N:13]=1.C(=O)([O-])[O-].[K+].[K+]>CS(C)=O>[Cl:18][C:17]1[C:12]([O:9][C:8]2[C:2]([Cl:1])=[CH:3][C:4]([NH2:5])=[CH:6][C:7]=2[Cl:10])=[N:13][CH:14]=[C:15]([O:19][CH:20]([F:22])[F:21])[CH:16]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 800374-Amino-2,6-dichlorophenolHCID 14556197HCID 14556197, compound

Product 1

HCID 20028636HCID 20028636, compound

Reagents, catalysts & solvents 1

HCID 679Dimethyl SulfoxideSolvent

Procedure

9.26 g (52 mmol) of 3,5-dichloro-4-hydroxyaniline, 10.1 g (50 mmol) of 2,3-dichloro-5-difluoromethoxypyridine and 10.4 g of anhydrous potassium carbonate were stirred for 15 hours at 105° C. under argon in 50 ml of anhydrous dimethyl sulfoxide. The dimethyl sulfoxide was then removed by distillation, and the residue was taken up in 100 ml of ether, washed twice with 30 ml of 5% strength potassium carbonate solution and with water until neutral and concentrated by evaporation.

Workup

  1. customThe dimethyl sulfoxide was then removed by distillation
  2. washwashed twice with 30 ml of 5% strength potassium carbonate solution and with water until neutral and
  3. concentrationconcentrated by evaporation

Sources & evidence

ORD record
ord-d3ad6e56bdf143c293ae9f471be26de7
Source dataset
uspto-grants-1988_07
Patent number
US04756739

Reaction notes

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