Hydrochloric Acid → HCID 44588576, compound

HRID 845216Notes

Reaction equation

HRID 845216 reaction equation
[NH2:1][C:2]1[C:19](=[O:20])[CH2:18][CH2:17][C@@:16]2([CH3:21])[C:3]=1[CH:4]=[CH:5][C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C:10]2=[O:22].[ClH:23]>C(O)C>[ClH:23].[NH2:1][C:2]1[C:19](=[O:20])[CH2:18][CH2:17][C@@:16]2([CH3:21])[C:3]=1[CH:4]=[CH:5][C@@H:6]1[C@@H:15]2[CH2:14][CH2:13][C@@:11]2([CH3:12])[C@H:7]1[CH2:8][CH2:9][C:10]2=[O:22]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 13714626HCID 13714626, compound

Product 1

HCID 44588576HCID 44588576, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 0.5 g of 4-aminoandrosta-4,6-dien-3,17-dione in 20 ml of ethanol is treated with 16.7 ml of 0.1N HCl aqueous solution. The yellow solution is then treated with 0.02 g of carbon, filtered and the alcohol is distilled at reduced pressure. The resulting aqueous solution is lyophilized to give 0.54 g of dry title compound as slight yellow powder.

Workup

  1. additionThe yellow solution is then treated with 0.02 g of carbon
  2. filtrationfiltered
  3. distillationthe alcohol is distilled at reduced pressure
  4. customto give 0.54 g
  5. dry with materialof dry title compound as slight yellow powder

Sources & evidence

ORD record
ord-0a6af415df1b43319675f92fbd490f01
Source dataset
uspto-grants-1988_07
Patent number
US04757061

Reaction notes

Loading…