反应详情

5-Acetoxymethyl-4-methoxymethyl-beta-carboline-3-carboxylic acid ethyl ester (7.9 g) is taken up in a solution of sodium (1.4 g) in ethanol (100 ml) and left for 4 days at +4° C. The solution is concentrated, taken up in abundant ethyl acetate, washed alkali-free with water, dried with sodium sulfate and evaporated in a vacuum. By treatment with ethanol the residue yields 6.6 g of the title compound as colorless crystals with a melting point of 139°-140° C.

1. concentrationThe solution is concentrated
2. washwashed alkali-free with water
3. dry with materialdried with sodium sulfate
4. customevaporated in a vacuum