Ethanol → HCID 70407477, compound

HRID 845239Notes

Reaction equation

HRID 845239 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[N:10](C(=O)C)[C:11]3[C:16]([C:17]=2[CH:18]=1)=[C:15](CCBr)[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].[NH:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1.O.[CH2:32](O)C>>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[C:8]([CH3:32])[C:9]2[NH:10][C:11]3[C:16]([C:17]=2[CH:18]=1)=[C:15]([N:25]1[CH2:30][CH2:29][O:28][CH2:27][CH2:26]1)[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Participants

5

Reactant 4

HCID 702EthanolHCID 962WaterHCID 8083MorpholineHCID 54319701HCID 54319701, compound

Product 1

HCID 70407477HCID 70407477, compound

Procedure

Under nitrogen, a solution of 0.19 g of 9-acetyl-5-bromoethyl-beta-carboline-3-carboxylic acid ethyl ester in 5 ml of ethanol is mixed with 1 ml of morpholine and stirred overnight at room temperature. After addition of water the crystallizate is suctioned off and recrystallized from ethanol/diethylether. 0.11 g (64%) is obtained. Melting point 285° C.

Workup

  1. customrecrystallized from ethanol/diethylether
  2. custom0.11 g (64%) is obtained

Sources & evidence

ORD record
ord-e92373eca9bc45ba85c0ed93dea926fe
Source dataset
uspto-grants-1988_07
Patent number
US04757070

Reaction notes

Loading…