Nitromethane → HCID 54347464, compound

HRID 845243Notes

Reaction equation

HRID 845243 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH:20]=O)[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2].[N+:22]([CH3:25])([O-:24])=[O:23].Cl.CN.C(=O)([O-])[O-].[Na+].[Na+]>C(O)C>[CH2:1]([O:3][C:4]([C:6]1[N:7]=[CH:8][C:9]2[NH:10][C:11]3[C:16]([C:17]=2[C:18]=1[CH3:19])=[C:15]([CH:20]=[CH:25][N+:22]([O-:24])=[O:23])[CH:14]=[CH:13][CH:12]=3)=[O:5])[CH3:2]

Participants

6

Reactant 4

HCID 6375NitromethaneHCID 10340Sodium CarbonateHCID 6364545Methylamine hydrochlorideHCID 54371401HCID 54371401, compound

Product 1

HCID 54347464HCID 54347464, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A solution of 5-formyl-4-methyl-beta-carboline-3-carboxylic acid ethyl ester (10 g), nitromethane (2 ml) and methylamine hydrochloride (0.2 g) in ethanol (50 ml) is mixed with sodium carbonate (0.3 g) and left for 5 days at 20° C. with occasional shaking. Then it is evaporated to beginning crystallization. 5 g of the title compound crystallizes from the solution cooled with ice water.

Workup

  1. customThen it is evaporated
  2. customcrystallization
  3. custom5 g of the title compound crystallizes from the solution
  4. temperaturecooled with ice water

Sources & evidence

ORD record
ord-5adfe4539b964b9f8851823f8deb2598
Source dataset
uspto-grants-1988_07
Patent number
US04757070

Reaction notes

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