HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-(3-nitrobenzylidene)-3-oxobutanoate → 1,4-Dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-(3-nitrobenzylidene)-3-oxobutanoate | HCID 367507 | — |
| Reactant | 3-Amino-crotonic acid-(2-phthalimido ethyl)ester | HCID 67903522 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 1,4-Dihydro-2,6-dimethyl-3-ethoxycarbonyl-4-(3-nitrophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine | HCID 13563415 | 89% |
Reaction Steps
Prepared by a method analogous to that of Example 1(a) from 15.80 g (60 mmol) of 2-(3-nitrobenzylidene)-acetoacetic acid ethyl ester and 16.46 g (60 mmol) of 3-amino-crotonic acid-(2-phthalimidoethyl)ester in ethanol. 27.75 g (89%) of yellow crystals melting at 194°-195° C. are obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04757080 |
| Source dataset | uspto-grants-1988_07 |
| ORD ID | ord-799ad69f58d540a6b6fd8df85bb0bc72 |
| Source note | uspto-grants-1988_07 |