Butanoic acid, 2-[(2,3-dichlorophenyl)methylene]-3-oxo-, methyl ester → 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(2,3-dichlorophenyl)-5-(2-phthalimidoethoxy)carbonyl-pyridine
Reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4](=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=1[Cl:16])[C:5]([CH3:7])=O.[C:18]1(=[O:37])[N:22]([CH2:23][CH2:24][O:25][C:26](=[O:31])/[CH:27]=[C:28](\[NH2:30])/[CH3:29])[C:21](=[O:32])[C:20]2=[CH:33][CH:34]=[CH:35][CH:36]=[C:19]12>>[CH3:7][C:5]1[NH:30][C:28]([CH3:29])=[C:27]([C:26]([O:25][CH2:24][CH2:23][N:22]2[C:21](=[O:32])[C:20]3=[CH:33][CH:34]=[CH:35][CH:36]=[C:19]3[C:18]2=[O:37])=[O:31])[CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([Cl:15])[C:10]=2[Cl:16])[C:4]=1[C:3]([O:2][CH3:1])=[O:17]Participants
3
Procedure
Prepared by a method analogous to that of Example 1(a) from 13.0 g (48 mmol) of 2-(2,3-dichlorobenzylidene)-acetoacetic acid methyl ester and 13.1 g (48 mmol) of 3-amino-crotonic acid-(2-phthalimido ethyl)ester. 14.2 g (57%) of pale yellow crystals melting at 195°-196° C.
Sources & evidence
- ORD record
- ord-f18fd49058c846ecba6d58a99a52a867
- Source dataset
- uspto-grants-1988_07
- Patent number
- US04757080
Reaction notes
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