Methyl 2-(2-nitrobenzylidene)acetoacetate → HCID 20132459, compound

HRID 845269Notes

Reaction equation

HRID 845269 reaction equation
[CH3:1][O:2][C:3](=[O:18])[C:4](=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=1[N+:15]([O-:17])=[O:16])[C:5]([CH3:7])=O.[C:19]1(=[O:40])[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][O:28][C:29](=[O:34])/[CH:30]=[C:31](\[NH2:33])/[CH3:32])[C:22](=[O:35])[C:21]2=[CH:36][CH:37]=[CH:38][CH:39]=[C:20]12>C(O)C>[CH3:7][C:5]1[NH:33][C:31]([CH3:32])=[C:30]([C:29]([O:28][CH2:27][CH2:26][CH2:25][CH2:24][N:23]2[C:19](=[O:40])[C:20]3=[CH:39][CH:38]=[CH:37][CH:36]=[C:21]3[C:22]2=[O:35])=[O:34])[CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N+:15]([O-:17])=[O:16])[C:4]=1[C:3]([O:2][CH3:1])=[O:18]

Participants

4

Reactant 2

HCID 787115Methyl 2-(2-nitrobenzylidene)acetoacetateHCID 67903649HCID 67903649, compound

Product 1

HCID 20132459HCID 20132459, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

13.7 g (55 mmol) of 2-(2-nitrobenzylidene)-acetoacetic acid methyl ester and 16.6 g (55 mmol) of 3-aminocrotonic acid-(4-phthalimido-butyl)ester are boiled in 150 ml of ethanol for 18 hours. The orange yellow oil (28.7 g-98%) obtained after removal of the solvent by evaporation under vacuum is used for further reactions without further purification.

Workup

  1. customThe orange yellow oil (28.7 g-98%) obtained
  2. customafter removal of the solvent
  3. customby evaporation under vacuum
  4. customis used for further reactions without further purification

Sources & evidence

ORD record
ord-a4feb850124e408295f40ff2f25c4718
Source dataset
uspto-grants-1988_07
Patent number
US04757080

Reaction notes

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