Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoate → 1,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-(11-phthalimido-undecyloxy)carbonyl-pyridine

HRID 845275노트

반응식

HRID 845275 반응식
[CH3:1][O:2][C:3](=[O:18])[C:4](=[CH:8][C:9]1[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=1)[C:5]([CH3:7])=O.[C:19]1(=[O:47])[N:23]([CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][O:35][C:36](=[O:41])/[CH:37]=[C:38](\[NH2:40])/[CH3:39])[C:22](=[O:42])[C:21]2=[CH:43][CH:44]=[CH:45][CH:46]=[C:20]12>CO>[CH3:7][C:5]1[NH:40][C:38]([CH3:39])=[C:37]([C:36]([O:35][CH2:34][CH2:33][CH2:32][CH2:31][CH2:30][CH2:29][CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][N:23]2[C:19](=[O:47])[C:20]3=[CH:46][CH:45]=[CH:44][CH:43]=[C:21]3[C:22]2=[O:42])=[O:41])[CH:8]([C:9]2[CH:14]=[CH:13][CH:12]=[C:11]([N+:15]([O-:17])=[O:16])[CH:10]=2)[C:4]=1[C:3]([O:2][CH3:1])=[O:18]

참가 물질

4

반응물 2

HCID 1536427Methyl 2-((3-nitrophenyl)methylene)-3-oxobutanoateHCID 679036883-Amino-crotonic acid-(11-phthalimido-undecyl)ester

생성물 1

HCID 201324901,4-Dihydro-2,6-dimethyl-3-methoxycarbonyl-4-(3-nitrophenyl)-5-(11-phthalimido-undecyloxy)carbonyl-pyridine수율 98%

시약·촉매·용매 1

HCID 887Methanol용매

실험 절차

Prepared by a method analogous to that of Example 1(a) from 9.33 g (37.5 mmol) of 2-(3-nitrobenzylidene)-acetoacetic acid methyl ester and 15.00 g (37.5 mmol) of 3-amino-crotonic acid-(11-phthalimido-undecyl)ester. 23.18 g (98%) of yellow crystals, melting point 130°-132° C., obtained from methanol.

출처 및 근거

ORD 기록
ord-61e341e2281a457cb5d5ada6e4335639
출처 데이터셋
uspto-grants-1988_07
특허 번호
US04757080

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