Formaldehyde → HCID 57221006, compound

HRID 845284Notes

Reaction equation

HRID 845284 reaction equation
[CH2:1]([N:8]([CH2:10][C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1)[OH:9])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH2:17]=O.[CH3:19][NH:20][CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1>>[CH2:10]([N:8]([CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)[O:9][CH2:19][N:20]([CH3:17])[CH2:21][CH2:22][C:23]1[CH:28]=[CH:27][CH:26]=[CH:25][N:24]=1)[C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][CH:12]=1

Participants

4

Reactant 3

HCID 712FormaldehydeHCID 2366BetahistineHCID 69297Dibenzylhydroxylamine

Product 1

HCID 57221006HCID 57221006, compound

Procedure

The procedure of Example I is repeated using 21.33 g of dibenzylhydroxylamine, 9.73 g of aqueous formaldehyde (37%) solution and 13.62 g of 2-[2-(N-methylamino)ethyl]pyridine, to afford the title compound.

Sources & evidence

ORD record
ord-f6276dd7263f4cfb9e26574570259c37
Source dataset
uspto-grants-1988_07
Patent number
US04757102

Reaction notes

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