1H-Imidazole-1-propanamine → N-(4-(3-(1H-imidazol-1-yl)propylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

HRID 84529Notes

Reaction equation

HRID 84529 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[N:11]([CH3:28])[C:12]([C:14]1[S:27][C:17]2[C:18]3[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=3[O:20][CH2:21][CH2:22][C:16]=2[CH:15]=1)=[O:13])[C:5]([OH:7])=O.[N:29]1([CH2:34][CH2:35][CH2:36][NH2:37])[CH:33]=[CH:32][N:31]=[CH:30]1>>[N:29]1([CH2:34][CH2:35][CH2:36][NH:37][C:5]([C:4]2[CH:8]=[CH:9][C:10]([N:11]([CH3:28])[C:12]([C:14]3[S:27][C:17]4[C:18]5[CH:26]=[CH:25][CH:24]=[CH:23][C:19]=5[O:20][CH2:21][CH2:22][C:16]=4[CH:15]=3)=[O:13])=[C:2]([Cl:1])[CH:3]=2)=[O:7])[CH:33]=[CH:32][N:31]=[CH:30]1

Participants

3

Reactant 2

HCID 787361H-Imidazole-1-propanamineHCID 668689233-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid

Product 1

HCID 57900425N-(4-(3-(1H-imidazol-1-yl)propylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

Procedure

3-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid and 3-(1H-imidazol-1-yl)propan-1-amine were reacted by a procedure similar to that to prepare 137 in Example 47 to give 229. MS: (ESI+) 521.1

Workup

  1. customthat to prepare 137 in Example 47

Sources & evidence

ORD record
ord-7796e3b69da349cea4b02668de942941
Source dataset
uspto-grants-2014_09
Patent number
US08846762B2

Reaction notes

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