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HRID 84529作成日：2026年10月25日

1H-Imidazole-1-propanamine → N-(4-(3-(1H-imidazol-1-yl)propylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamide

https://huagongshe.com/reaction/84529

反応式

関与物質

役割名称HCID仕込み量
反応物1H-Imidazole-1-propanamineHCID 78736—
反応物3-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acidHCID 66868923—
生成物N-(4-(3-(1H-imidazol-1-yl)propylcarbamoyl)-2-chlorophenyl)-N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamideHCID 57900425—

反応手順

3-Chloro-4-(N-methyl-4,5-dihydrobenzo[b]thieno[2,3-d]oxepine-2-carboxamido)benzoic acid and 3-(1H-imidazol-1-yl)propan-1-amine were reacted by a procedure similar to that to prepare 137 in Example 47 to give 229. MS: (ESI+) 521.1

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US08846762B2
出典データセットuspto-grants-2014_09
ORD IDord-7796e3b69da349cea4b02668de942941
出典メモuspto-grants-2014_09