反应详情

A solution of 0.14 g (1.2 mmol) of tert-butylacetic acid in 5 ml of ethyl acetate was treated with 0.367 g (2.4 mmol) of hydroxybenzothiazole hydrate, and 0.247 g (1.2 mmol) of dicyclohexylcarbodiimide. After stirring at room temperature for one hour, the product of Example 12 (0.321 g, 1 mmol) was added, together with a few additional milliliters of ethyl acetate. This mixture was stirred overnight at room temperature, and the crude product isolated. Following purification by column chromatography on silica gel, there was obtained 0.095 g of (±)-α-[(2,3-dimethyl-1-oxobutyl)-amino ]-α-methyl-N-(2-phenylethyl)-1H-indole-3-propanamide, mp 104°-109° C.

1. stirringThis mixture was stirred overnight at room temperature
2. customthe crude product isolated
3. custompurification by column chromatography on silica gel